Project acronym: LIVERHOPE

Project full title: "Simvastatin and Rifaximin as new therapy for patients with decompensated cirrhosis"

Publications


1. Núria Fabrellas, Patrizia Künzler-Heule, Amy Olofson, Kathryn Jack, Marta Carol.

pdf Nursing Care For Patients With Cirrhosis

J Hepatol 2023 Feb 6;S0168-8278(23)00082-X. DOI: 10.1016/j.jhep.2023.01.029.


2. Koos de Wit, Ulrich Beuers, Anna Mukha, Edwin C A Stigter, M Can Gulersonmez, Jose M Ramos Pittol, Sabine Middendorp, R Bart Takkenberg, Saskia W C van Mil.

pdf Rifaximin stimulates nitrogen detoxification by PXR-independent mechanisms in human small intestinal organoids

Liver Int, 2023 Mar;43(3):649-659. DOI: 10.1111/liv.15491. Epub 2022 Dec 20.


3. Cristina Ortiz, Sabine Klein, Winfried H Reul, Fernando Magdaleno, Stefanie Gröschl, Peter Dietrich, Robert Schierwagen, Frank E Uschner, Sandra Torres, Christoph Hieber, Caroline Meier, Nico Kraus, Olaf Tyc, Maximilian Brol, Stefan Zeuzem, Christoph Welsch, Marco Poglitsch, Claus Hellerbrand, Mercedes Alfonso-Prieto, Fabio Mira, Ulrich Auf dem Keller, Anja Tetzner, Andrew Moore, Thomas Walther, Jonel Trebicka.

pdf Neprilysin-dependent neuropeptide Y cleavage in the liver promotes fibrosis by blocking NPY-receptor 1

Cell Rep, 2023 Jan 31;42(2):112059. DOI: 10.1016/j.celrep.2023.112059. Online ahead of print.


4. Nadine Bachtler, Sandra Torres, Cristina Ortiz, Robert Schierwagen, Olaf Tyc, Christoph Hieber, Marie-Luise Berres, Caroline Meier, Nico Kraus, Stefan Zeuzem, Bart Nijmeijer, Sebas Pronk, Jonel Trebicka, Sabine Klein.

pdf The non-selective Rho-kinase inhibitors Y-27632 and Y-33075 decrease contraction but increase migration in murine and human hepatic stellate cells

PLoS One 2023 Jan 31;18(1):e0270288. DOI: 10.1371/journal.pone.0270288. eCollection 2023.


5. Tilman Sauerbruch, Martin Hennenberg, Jonel Trebicka,and Robert Schierwagen.

pdf Beta-blockers in patients with liver cirrhosis: Pragmatism or perfection?

Front Med (Lausanne). 2022; 9: 1100966. Published online 2023 Jan 9. DOI: 10.3389/fmed.2022.1100966


6. Anton Faron, Jasmin Abu-Omar, Johannes Chang, Nina Böhling, Alois Martin Sprinkart, Ulrike Attenberger, Jürgen K Rockstroh, Andreas Minh Luu, Christian Jansen, Christian P Strassburg, Jonel Trebicka, Julian Luetkens, Michael Praktiknjo.

pdf Combination of Fat-Free Muscle Index and Total Spontaneous Portosystemic Shunt Area Identifies High-Risk Cirrhosis Patients

Front Med (Lausanne) 2022 Apr 12;9:831005. DOI: 10.3389/fmed.2022.831005. eCollection 2022.


7. Sandra Torres, Maximilian J Brol, Fernando Magdaleno, Robert Schierwagen, Frank E. Uschner, Sabine Klein, Cristina Ortiz, Olaf Tyc, Nadine Bachtler, James Stunden, Damien Bertheloot, Ana Kitanovic, Brian Sanchez, Jacob Schrum, William R. Roush, Luigi Franchi, Kate Byth, Eicke Latz, and Jonel Trebicka.

pdf The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis

Front Mol Biosci. 2021; 8: 715765. Published online 2021 Aug 13.DOI: 10.3389/fmolb.2021.715765


8. Giacomo Zaccherini, Manuel Tufoni, Mauro Bernardi and Paolo Caraceni.

pdf Prevention of Cirrhosis Complications: Looking for Potential Disease Modifying Agents.

J. Clin. Med. 2021, 10(19), 4590. DOI: https://doi.org/10.3390/jcm10194590.


9. Giacomo Zaccherini, Manuel Tufoni, Giulia Iannone and Paolo Caraceni.

pdf Management of Ascites in Patients with Cirrhosis: An Update.

J. Clin. Med. 2021, 10(22), 5226. DOI: https://doi.org/10.3390/jcm10225226


10. Alexander Queck, Dominique Thomas, Christian Jansen, Yannick Schreiber, Sabrina Rüschenbaum, Michael Praktiknjo, Katharina Maria Schwarzkopf, Marcus Maximilian Mücke, Robert Schierwagen, Frank Erhard Uschner, Carsten Meyer, Joan Clària, Stefan Zeuzem, Gerd Geisslinger, Jonel Trebicka, Christian Markus Lange.

pdf Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis.

PLoS One 2019 Oct 23;14(10):e0222840. DOI: 10.1371/journal.pone.0222840. eCollection 2019.


11. Michael Praktiknjo, Jasmin Abu-Omar, Johannes Chang, Daniel Thomas, Christian Jansen, Patrick Kupczyk, Filippo Schepis, Juan Carlos Garcia-Pagan, Manuela Merli, Carsten Meyer, Christian P. Strassburg, Claus C. Pieper, and Jonel Trebicka.

pdf Controlled underdilation using novel VIATORR® controlled expansion stents improves survival after transjugular intrahepatic portosystemic shunt implantation.

JHEP Rep. 2021 Jun; 3(3): 100264. DOI: 10.1016/j.jhepr.2021.100264


12. Carla Cremonese, Robert Schierwagen, Frank Erhard Uschner, Sandra Torres, Olaf Tyc , Cristina Ortiz , Martin Schulz , Alexander Queck , Glen Kristiansen, Michael Bader, Tilman Sauerbruch, Ralf Weiskirchen, Thomas Walther, Jonel Trebicka, Sabine Klein.

pdf Short-Term Western Diet Aggravates Non-Alcoholic Fatty Liver Disease (NAFLD) With Portal Hypertension in TGR(mREN2)27 Rats.

Int J Mol Sci. 2020 May 7;21(9):3308. DOI: 10.3390/ijms21093308.


13. Alexander Queck, Roberto Carnevale, Frank Erhard Uschner, Robert Schierwagen, Sabine Klein, Christian Jansen, Carsten Meyer, Michael Praktiknjo, Daniel Thomas, Christian Strassburg, Stefan Zeuzem, Francesco Violi, Jonel Trebicka.

pdf Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS.

Gut. 2020 Aug;69(8):1535-1536. DOI: 10.1136/gutjnl-2019-319044. Epub 2019 Jul 3.


14. Stephen Casey, Robert Schierwagen, Kai Yan Mak, Sabine Klein, Frank Uschner, Christian Jansen, Michael Praktiknjo, Carsten Meyer, Daniel Thomas, Chandana Herath, Robert Jones 1, Jonel Trebicka, and Peter Angus.

pdf Activation of the Alternate Renin-Angiotensin System Correlates with the Clinical Status in Human Cirrhosis and Corrects Post Liver Transplantation.

Journal of Clinical Medicine, 27 Mar 2019, 8(4):E419 DOI: 10.3390/jcm8040419


15. Michael Praktiknjo, Caroline Clees, Alessandra Pigliacelli, Stefan Fischer, Christian Jansen, Jennifer Lehmann, Alessandra Pohlmann, Barbara Lattanzi, Viktoria Katharina Krabbe, Christian P. Strassburg, Vicente Arroyo, Manuela Merli, Carsten Meyer, and Jonel Trebicka.

pdf Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt.

Clinical and Translational Gastroenterology, 01 Apr 2019, 10(4):e00025. DOI: 10.14309/ctg.0000000000000025


16. Michael Praktiknjo, Sofia Monteiro, Josephine Grandt, Nina Kimer, Jan L. Madsen, Mikkel P. Werge, Peter William, Maximilian J. Brol, Laura Turco, Robert Schierwagen, Johannes Chang, Sabine Klein, Frank E. Uschner, Christoph Welsch, Richard Moreau, Filippo Schepis, Flemming Bendtsen, Lise L. Gluud, Søren Møller, Jonel Trebicka.

pdf Cardiodynamic state is associated with systemic inflammation and fatal acute‐on‐chronic liver failure.

Liver International Volume40, Issue6 June 2020 Pages 1457-1466. DOI: https://doi.org/10.1111/liv.14433


17. Christian Jansen, Anna Schröder, Robert Schueler, Jennifer Lehmann, Michael Praktiknjo, Frank E Uschner, Robert Schierwagen, Daniel Thomas, Sofia Monteiro, Georg Nickenig, Christian P Strassburg, Carsten Meyer, Vicente Arroyo, Christoph Hammerstingl, Jonel Trebicka.

pdf Left Ventricular Longitudinal Contractility Predicts Acute-on-Chronic Liver Failure Development and Mortality After Transjugular Intrahepatic Portosystemic Shunt.

Hepatol Commun 2019 Jan 22;3(3):340-347. DOI: 10.1002/hep4.1308. eCollection 2019 Mar.


18. Elisa Pose, Laura Napoleone, Ahmed Amin, Daniela Campion, César Jimenez, Salvatore Piano, Olivier Roux, Frank Erhard Uschner, Koos de Wit, Giacomo Zaccherini, Carlo Alessandria, Paolo Angeli, Mauro Bernardi, Ulrich Beuers, Paolo Caraceni, François Durand, Rajeshwar P Mookerjee, Jonel Trebicka, Victor Vargas, Raúl J Andrade, Marta Carol, Judit Pich, Juan Ferrero, Gema Domenech, Marta Llopis, Ferran Torres, Patrick S Kamath, Juan G Abraldes, Elsa Solà, Pere Ginès.

pdf Safety of two different doses of simvastatin plus rifaximin in decompensated cirrhosis (LIVERHOPE-SAFETY): a randomised, double-blind, placebo-controlled, phase 2 trial.

Lancet Gastroenterol Hepatol. 2020 Jan;5(1):31-41. DOI: 10.1016/S2468-1253(19)30320-6. Epub 2019 Oct 10.


19. Tom H Karlsen, Nick Sheron, Shira Zelber-Sagi, Patrizia Carrieri, Geoffrey Dusheiko, Elisabetta Bugianesi, Rachel Pryke, Sharon J Hutchinson, Bruno Sangro, Natasha K Martin, Michele Cecchini, Mae Ashworth Dirac, Annalisa Belloni, Miquel Serra-Burriel, Cyriel Y Ponsioen, Brittney Sheena, Alienor Lerouge, Marion Devaux, Nick Scott, Margaret Hellard, Henkjan J Verkade, Ekkehard Sturm, Giulio Marchesini, Hannele Yki-Järvinen, Chris D Byrne, Giovanni Targher, Aviad Tur-Sinai, Damon Barrett, Michael Ninburg, Tatjana Reic, Alison Taylor, Tim Rhodes, Carla Treloar, Claus Petersen, Christoph Schramm, Robert Flisiak, Marieta Y Simonova, Albert Pares, Philip Johnson, Alessandro Cucchetti, Isabel Graupera, Christos Lionis, Elisa Pose, Núria Fabrellas, Ann T Ma, Juan M Mendive, Vincenzo Mazzaferro, Harry Rutter, Helena Cortez-Pinto, Deirdre Kelly, Robyn Burton, Jeffrey V Lazarus, Pere Ginès, Maria Buti, Philip N Newsome, Patrizia Burra, Michael P Manns.

pdf The EASL-Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality.

Lancet, 2022 Jan 1;399(10319):61-116. DOI: 10.1016/S0140-6736(21)01701-3. Epub 2021 Dec 2.


20. Paolo Caraceni, Alastair O’Brien, Pere Gines.

pdf Long-term albumin treatment in patients with cirrhosis and ascites.

Journal of Hepatology Volume 76, Issue 6, June 2022, Pages 1306-1317. DOI: https://doi.org/10.1016/j.jhep.2022.03.005


21. Adrià Juanola, Isabel Graupera, Chiara Elia, Salvatore Piano, Cristina Solé, Marta Carol, Martina Pérez-Guasch, Octavi Bassegoda, Laia Escudé, AnaBelén Rubio, Marta Cervera, Laura Napoleone, Emma Avitabile, AnnT. Ma, Núria Fabrellas, Elisa Pose, Manuel Morales Ruiz, Wladimiro Jiménez, Ferran Torres, Gonzalo Crespo, Pere Ginès.

pdf Urinary L-FABP is a promising prognostic biomarker of ACLF and mortality in patients with decompensated cirrhosis.

Journal of Hepatology Volume 76, Issue 1, January 2022, Pages 107-114. DOI: https://doi.org/10.1016/j.jhep.2021.08.031


22. Paolo Caraceni, Juan G Abraldes, Pere Ginès, Phil N Newsome, Shiv K Sarin.

pdf The search for disease-modifying agents in decompensated cirrhosis: From drug repurposing to drug discovery.

J Hepatol 2021 Jul;75 Suppl 1:S118-S134. DOI: 10.1016/j.jhep.2021.01.024


23. Elisa Pose, Mar Coll, Celia Martínez-Sánchez, Zhutian Zeng, Bas G. J. Surewaard, Cristina Català, María Velasco-de Andrés, Juan José Lozano, Sílvia Ariño, David Fuster, Aida Niñerola‐Bazán, Isabel Graupera, Érica Muñoz, Francisco Lozano, Pau Sancho-Bru, Paul Kubes, and Pere Ginès.

pdf Programmed Death Ligand 1 Is Overexpressed in Liver Macrophages in Chronic Liver Diseases, and Its Blockade Improves the Antibacterial Activity Against Infections.

Hepatology. 2021 Jul; 74(1): 296–311. DOI: 10.1002/hep.31644


24. Piano S, Tonon M, Angeli P.

pdf Changes in the epidemiology and management of bacterial infections in cirrhosis.

Clin Mol Hepatol. 2021 Jul;27(3):437-445. doi: 10.3350/cmh.2020.0329. Epub 2021 Jan 28. PMID: 33504138; PMCID: PMC8273641.


25. Reiberger T, Berzigotti A, Trebicka J, Ertle J, Gashaw I, Swallow R, Tomisser A.

pdf The rationale and study design of two phase II trials examining the effects of BI 685,509, a soluble guanylyl cyclase activator, on clinically significant portal hypertension in patients with compensated cirrhosis.

Trials. 2023 Apr 24;24(1):293. doi: 10.1186/s13063-023-07291-3. PMID: 37095557; PMCID: PMC10123479.


26. Allegretti AS, Solà E, Ginès P.

pdf Clinical Application of Kidney Biomarkers in Cirrhosis.

Am J Kidney Dis. 2020 Nov;76(5):710-719. doi: 10.1053/j.ajkd.2020.03.016. Epub 2020 Jul 1. PMID: 32622560.


27. Tantai X, Liu Y, Yeo YH, Praktiknjo M, Mauro E, Hamaguchi Y, Engelmann C, Zhang P, Jeong JY, van Vugt JLA, Xiao H, Deng H, Gao X, Ye Q, Zhang J, Yang L, Cai Y, Liu Y, Liu N, Li Z, Han T, Kaido T, Sohn JH, Strassburg C, Berg T, Trebicka J, Hsu YC, IJzermans JNM, Wang J, Su GL, Ji F, Nguyen MH.

pdf Effect of sarcopenia on survival in patients with cirrhosis: A meta-analysis.

J Hepatol. 2022 Mar;76(3):588-599. doi: 10.1016/j.jhep.2021.11.006. Epub 2021 Nov 14. PMID: 34785325.


28. Isabel Graupera, Laura Isus, Mar Coll, Elisa Pose, Alba Díaz, Julia Vallverdú,Teresa Rubio-Tomás,Celia Martínez-Sánchez, Patricia Huelin, Marta Llopis, Cristina Solé, Constantino Fondevila, Juan José Lozano, Pau Sancho-Bru, Pere Ginès, Patrick Aloy.

pdf Molecular characterization of chronic liver disease dynamics: from liver fibrosis to acute-on-chronic liver failure

JHEP Reports April 04, 2022 DOI: https://doi.org/10.1016/j.jhepr.2022.100482.


29. Marta Carol, Martina Pérez-Guasch, Elsa Solà, Marta Cervera, Sara Martínez, Adrià Juanola, Ann T Ma, Emma Avitabile, Laura Napoleone, Elisa Pose, Isabel Graupera, Maria Honrubia, Marko Korenjak, Ferran Torres, Pere Ginès, Núria Fabrellas, LiverHope Consortium Investigators.

pdf Stigmatization is common in patients with non-alcoholic fatty liver disease and correlates with quality of life

PLoS One 2022 Apr 6;17(4):e0265153. doi: 10.1371/journal.pone.0265153. eCollection 2022.


29. Elisa Pose , Elsa Solà, Juan J Lozano, Adrià Juanola, Julia Sidorova, Giacomo Zaccherini, Koos de Wit , Frank Uschner, Marta Tonon, Konstantin Kazankov, Cesar Jiménez, Daniela Campion, Laura Napoleone, Ann T Ma, Marta Carol, Manuel Morales-Ruiz , Carlo Alessandria, Ulrich Beuers, Paolo Caraceni, Claire Francoz, François Durand, Rajeshwar P Mookerjee, Jonel Trebicka, Victor Vargas, Salvatore Piano, Hugh Watson, Juan G Abraldes, Patrick S Kamath 17, Mark M Davis , Pere Ginès , investigators of the LIVERHOPE Consortium.

pdf Treatment With Simvastatin and Rifaximin Restores the Plasma Metabolomic Profile in Patients With Decompensated Cirrhosis

Hepatol Commun 2021 Dec 28. doi: 10.1002/hep4.1881. Online ahead of print.


30. Cristina Solé, Susie Guilly, Kevin Da Silva, Marta Llopis, Emmanuelle Le-Chatelier, Patricia Huelin, Marta Carol, Rebeca Moreira, Núria Fabrellas, Gloria De Prada, Laura Napoleone, Isabel Graupera, Elisa Pose, Adrià Juanola, Natalia Borruel, Magali Berland, David Toapanta, Francesc Casellas, Francisco Guarner, Jöel Doré, Elsa Solà, Stanislav Dusko Ehrlich, and Pere Ginès.

pdf Alterations in Gut Microbiome in Cirrhosis as Assessed by Quantitative Metagenomics: Relationship With Acute-on-Chronic Liver Failure and Prognosis

Gastroenterology 2021;160:206–218. doi: https://doi.org/10.1053/j.gastro.2020.08.054.


31. Jonel Trebicka, Jane Macnaughtan, Bernd Schnabl, Debbie L. Shawcross, Jasmohan S. Bajaj.

pdf The microbiota in cirrhosis and its role in hepatic decompensation

J Hepatol 2021 Jul;75 Suppl 1:S67-S81. doi: 10.1016/j.jhep.2020.11.013.


32. Michael Praktiknjo, Jasmin Abu-Omar, Johannes Chang, Daniel Thomas, Christian Jansen, Patrick Kupczyk, Filippo Schepis, Juan Carlos Garcia-Pagan, Manuela Merli, Carsten Meyer, Christian P. Strassburg, Claus C. Pieper, Jonel Trebicka.

pdf Controlled underdilation using novel VIATORR® controlled expansion stents improves survival after transjugular intrahepatic portosystemic shunt implantation

JHEP Rep 2021 Mar 3;3(3):100264. doi: 10.1016/j.jhepr.2021.100264. eCollection 2021 Jun.


33. Philip Ferstl, Jonel Trebicka.

pdf Acute Decompensation and Acute-on-Chronic Liver Failure

Clinics in Liver Disease 2021 25/2 419-430. doi: 10.1016/j.cld.2021.01.009.


34. Jonel Trebicka, Wenyi Gu, Victor de Ledinghen, Christophe Aubé, Aleksander Krag, Michael Praktiknjo, Laurent Castera, Jerome Dumortier, David Josef Maria Bauer, Mireen Friedrich-Rust, Stanislas Pol, Ivica Grgurevic, Rongqin Zheng, Sven Francque, Halima Gottfriedovà, Sanda Mustapic, Ioan Sporea, Annalisa Berzigotti, Frank Erhard Uschner, Benedikt Simbrunner, Maxime Ronot, Christophe Cassinotto, Maria Kjaergaard, Filipe Andrade, Martin Schulz, Georg Semmler, Ida Tjesic Drinkovic, Johannes Chang, Maximilian Joseph Brol, Pierre Emmanuel Rautou, Thomas Vanwolleghem, Christian P Strassburg, Jerome Boursier, Philip Georg Ferstl, Ditlev Nytoft Rasmussen, Thomas Reiberger, Valerie Vilgrain, Aymeric Guibal, Olivier Guillaud, Stefan Zeuzem, Camille Vassord, Xue Lu, Luisa Vonghia, Renata Senkerikova, Alina Popescu, Cristina Margini, Wenping Wang, Maja Thiele, Chrisitan Jansen.

pdf Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease

Gut 2021 Jan 21;gutjnl-2020-323419. doi: 10.1136/gutjnl-2020-323419. Online ahead of print.


35. Sofia Monteiro, Josephine Grandt, Frank Erhard Uschner, Nina Kimer, Jan Lysgård Madsen, Robert Schierwagen, Sabine Klein, Christoph Welsch, Liliana Schäfer, Christian Jansen, Joan Claria, José Alcaraz-Quiles, Vicente Arroyo, Richard Moreau, Javier Fernandez, Flemming Bendtsen, Gautam Mehta, Lise Lotte Gluud, Søren Møller, Michael Praktiknjo, Jonel Trebicka.

pdf Differential inflammasome activation predisposes to acute-on-chronic liver failure in human and experimental cirrhosis with and without previous decompensation

Gut 2021 Feb;70(2):379-387. doi: 10.1136/gutjnl-2019-320170. Epub 2020 Apr 2.


36. Delia Blaya, Elisa Pose, Mar Coll, Juan José Lozano, Isabel Graupera, Robert Schierwagen, Christian Jansen, Pedro Castro, Sara Fernandez, Julia Sidorova, Mariuca Vasa-Nicotera, Elsa Solà, Joan Caballería, Jonel Trebicka, Pere Ginès, Pau Sancho-Bru.

pdf Profiling circulating microRNAs in patients with cirrhosis and acute-on-chronic liver failure

JHEP Reports 2021 Volume 3, Issue 2 doi: https://doi.org/10.1016/j.jhepr.2021.100233.


37. Paolo Caraceni, Victor Vargas, Elsa Solà, Carlo Alessandria, Koos de Wit, Jonel Trebicka, Paolo Angeli, Rajeshwar P. Mookerjee, François Durand, Elisa Pose, Aleksander Krag, Jasmohan S. Bajaj, Ulrich Beuers, Pere Ginès.

pdf The use of Rifaximin in Patients with Cirrhosis

Hepatology 2021 Jan 9. doi: 10.1002/hep.31708. Online ahead of print.


38.Solà E, Pose E, Campion D, Piano S, Roux O, Simon-Talero M, Uschner F, de Wit K, Zaccherini G, Alessandria C, Beuers U, Caraceni P, Francoz C, Mookerjee R, Trebicka J, Vargas V, Serra M, Torres F, Montagnese S, Krag A, Hernáez R, Korenjak M, Watson H, Abraldes JG, Kamath P, Ginès P; LiverHope Consortium Investigators.

pdf ENDPOINTS AND DESIGN OF CLINICAL TRIALS IN PATIENTS WITH DECOMPENSATED CIRRHOSIS: POSITION PAPER OF THE LIVERHOPE CONSORTIUM

J Hepatol 2021, January, Volume 74, Issue 1, Pages 200-219, https://doi.org/10.1016/j.jhep.2020.08.009.


39. Katharina Maria Schwarzkopf, Larissa Eberle, Frank Erhard Uschner, Sabine Klein, Robert Schierwagen, Marcus Maximilian Mücke, Liliana Schaefer, Joan Clària, Stefan Zeuzem, Edith Hintermann, Urs Christen, Christian Markus Lange, Jonel Trebicka, Christoph Welsch.

pdf Interleukin-22 in acute-on-chronic liver failure: A matter of ineffective levels, receptor dysregulation or defective signalling?

J Hepatol 2020 Oct;73(4):980-982. doi: 10.1016/j.jhep.2020.05.012. Epub 2020 Jul 19.


40. Carla Cremonese, Robert Schierwagen, Frank Erhard Uschner, Sandra Torres, Olaf Tyc, Cristina Ortiz, Martin Schulz, Alexander Queck, Glen Kristiansen, Michael Bader, Tilman Sauerbruch, Ralf Weiskirchen, Thomas Walther, Jonel Trebicka, Sabine Klein.

pdf Short-Term Western Diet Aggravates Non-Alcoholic Fatty Liver Disease (NAFLD) With Portal Hypertension in TGR(mREN2)27 Rats

Int J Mol Sci 2020 May 7;21(9):3308. doi: 10.3390/ijms21093308.


41. Jonel Trebicka, Vinay Sundaram, Richard Moreau, Rajiv Jalan, Vicente Arroyo.

pdf Liver Transplantation for Acute‐on‐Chronic Liver Failure: Science or Fiction?

Liver Transpl 2020 Jul;26(7):906-915. doi: 10.1002/lt.25788.


42. Fabian Benz, Andreas Bogen, Michael Praktiknjo, Christian Jansen, Carsten Meyer, Alexander Wree, Muenevver Demir, Sven Loosen, Mihael Vucur, Robert Schierwagen, Frank Tacke, Jonel Trebicka, Christoph Roderburg.

pdf Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis

PLoS One 2020 Apr 17;15(4):e0231701. doi: 10.1371/journal.pone.0231701. eCollection 2020.


43. Alexander Queck, Hannah Bode, Frank E. Uschner, Maximilian J. Brol, Christiana Graf, Martin Schulz, Christian Jansen, Michael Praktiknjo, Robert Schierwagen, Sabine Klein, Christian Trautwein, Hermann E. Wasmuth, Marie-Luise Berres, Jonel Trebicka, Jennifer Lehmann.

pdf Systemic MCP-1 Levels Derive Mainly From Injured Liver and Are Associated With Complications in Cirrhosis

Front Immunol 2020 Mar 11;11:354. doi: 10.3389/fimmu.2020.00354. eCollection 2020.


44. Giuseppe Cullaro, Rajani Sharma, Jonel Trebicka, Andrés Cárdenas, Elizabeth C. Verna.

pdf Precipitants of Acute‐on‐Chronic Liver Failure: An Opportunity for Preventative Measures to Improve Outcomes

Liver Transpl 2020 Feb;26(2):283-293. doi: 10.1002/lt.25678. Epub 2020 Jan 6.


45. Maria Torner, Adjmal Mangal, Hubert Scharnagl, Christian Jansen, Michael Praktiknjo, Alexander Queck, Wenyi Gu, Robert Schierwagen, Jennifer Lehmann, Frank E. Uschner, Christiana Graf, Christian P. Strassburg, Javier Fernandez, Tatjana Stojakovic, Rainer Woitas, Jonel Trebicka.

pdf Sex specificity of kidney markers to assess prognosis in cirrhotic patients with TIPS

Liver Int 2020 Jan;40(1):186-193. doi: 10.1111/liv.14230. Epub 2019 Sep 10.


46. Alexander Queck, Roberto Carnevale, Frank Erhard Uschner, Robert Schierwagen, Sabine Klein, Christian Jansen, Carsten Meyer, Michael Praktiknjo, Daniel Thomas, Christian Strassburg, Stefan Zeuzem, Francesco Violi, Jonel Trebicka.

pdf Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS

Gut 2020 Aug;69(8):1535-1536. doi: 10.1136/gutjnl-2019-319044. Epub 2019 Jul 3.


47. Michael Praktiknjo, Sofia Monteiro, Josephine Grandt, Nina Kimer, Jan L. Madsen, Mikkel P. Werge, Peter William, Maximilian J. Brol, Laura Turco, Robert Schierwagen, Johannes Chang, Sabine Klein, Frank E. Uschner, Christoph Welsch, Richard Moreau, Filippo Schepis, Flemming Bendtsen, Lise L. Gluud, Søren Møller, Jonel Trebicka.

pdf Cardiodynamic state is associated with systemic inflammation and fatal acute‐on‐chronic liver failure

Liver International 2020 , 40/6, 1457-1466. doi: 10.1111/liv.14433.


48. Fabrellas N, Carol M, Palacio E, Aban M, Lanzillotti T, Nicolao G, Chiappe MT, Esnault V, Graf‐Dirmeier S, Helder J, Gossard A, Lopez M, Cervera M, Dols LL, The LiverHope consortium investigators.

pdf Nursing care of patients with cirrhosis

Hepatology 2020 Jan 16. doi: 10.1002/hep.31117.


49. Alexander Queck, Dominique Thomas, Christian Jansen, Yannick Schreiber, Sabrina Rüschenbaum, Michael Praktiknjo, Katharina Maria Schwarzkopf, Marcus Maximilian Mücke, Robert Schierwagen, Frank Erhard Uschner, Carsten Meyer, Joan Clària, Stefan Zeuzem, Gerd Geisslinger, Jonel Trebicka, Christian Markus Lange.

pdf Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis

PLoS One 2019 Oct 23;14(10):e0222840. doi: 10.1371/journal.pone.0222840. eCollection 2019.


50. Stephen Casey, Robert Schierwagen, Kai Mak, Sabine Klein, Frank Uschner, Christian Jansen, Michael Praktiknjo, Carsten Meyer, Daniel Thomas, Chandana Herath, Robert Jones, Jonel Trebicka, Peter Angus.

pdf Activation of the Alternate Renin-Angiotensin System Correlates with the Clinical Status in Human Cirrhosis and Corrects Post Liver Transplantation

J. Clin. Med. 2019, 8(4), 419. doi: https://doi.org/10.3390/jcm8040419.


51. Michael Praktiknjo, Caroline Clees, Alessandra Pigliacelli, Stefan Fischer, Christian Jansen, Jennifer Lehmann, Alessandra Pohlmann, Barbara Lattanzi, Viktoria Katharina Krabbe, Christian P. Strassburg, Vicente Arroyo, Manuela Merli, Carsten Meyer, Jonel Trebicka.

pdf Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt

Clinical and Translational Gastroenterology 01 Apr 2019, 10(4):e00025. doi: 10.14309/ctg.0000000000000025.


52. Christian Jansen, Anna Schröder, Robert Schueler, Jennifer Lehmann, Michael Praktiknjo, Frank E. Uschner, Robert Schierwagen, Daniel Thomas, Sofia Monteiro, Georg Nickenig, Christian P. Strassburg, Carsten Meyer, Vicente Arroyo, Christoph Hammerstingl, Jonel Trebicka..

pdf Left Ventricular Longitudinal Contractility Predicts Acute-on-Chronic Liver Failure Development and Mortality After Transjugular Intrahepatic Portosystemic Shunt

Hepatol Commun 2019 Jan 22;3(3):340-347. doi: 10.1002/hep4.1308. eCollection 2019 Mar.


53. Solé C, Solà E, Huelin P, Carol M, Moreira R, Cereijo U, Mas JM, Graupera I, Pose E, Napoleone L, dePrada G, Juanola A, Fabrellas N, Torres F, Morales‐Ruiz M, Farrés J, Jiménez W,  Ginès P.

pdf Characterization of inflammatory response in hepatorenal syndrome: Relationship with kidney outcome and survival

Liver Int. 2018 Dec 29. doi: 10.1111/liv.14037.


54. Pose E, Trebicka J, Mookerjee RP, Angeli P, Ginès P.

pdf Statins: Old drugs as new therapy for liver diseases?

J Hepatol. 2018 Aug.


55. Ginès P, Shiv, S.

pdf More Than Meets the Eye in Using Interleukin 6 as a Marker of Inflammation and Prognostic Factor for Patients With Cirrhosis.

Clinical Gastroenterology and Hepatology. 2018;16:630-632.


56. Solé C, Pose E, Solà E, Ginès P.

pdf Hepatorenal syndrome in the era of acute kidney injury.

Liver Int. 2018;00:1-11.


57. Hernaez R, Solà E, Moreau R, Ginès P.

pdf Acute-on-chronic liver failure: an update.

Gut. 2017 Mar;66(3):541-553. doi: 10.1136/gutjnl-2016-312670. Epub 2017 Jan 4.